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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Long non-coding RNA regulation of TRAIL in breast cancer: A tangle of non-coding threads

Zeeshan Javed1, Khushbukhat Khan2, Muhammad Zaheer Iqbal3

  • 1Office for Research Innovation and Commercialization, Lahore Garrison University, Lahore, Punjab 54792, Pakistan.

Oncology Letters
|August 18, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate breast cancer progression and drug resistance. This review explores lncRNA interplay with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling, offering new therapeutic strategies for breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer presents a significant global health challenge due to its complex molecular characteristics and heterogeneity.
  • Tumor heterogeneity contributes to drug resistance, metastasis, and invasiveness in breast cancer.
  • Despite advancements, effective breast cancer cures remain elusive, highlighting the need for novel therapeutic targets.

Purpose of the Study:

  • To elucidate the role of long non-coding RNAs (lncRNAs) in regulating breast cancer.
  • To investigate the interplay between lncRNAs and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling in breast cancer.
  • To explore the potential of lncRNA-TRAIL interactions as a basis for new breast cancer diagnostics and therapeutics.

Main Methods:

  • Literature review focusing on lncRNAs in breast cancer.
  • Analysis of existing studies on apoptosis regulation in breast cancer.
  • Examination of the mechanisms underlying TRAIL signaling pathway in breast cancer.

Main Results:

  • lncRNAs are implicated in breast cancer development, proliferation, and metastasis.
  • Dysregulation of apoptosis is a key factor in breast cancer progression and treatment resistance.
  • lncRNAs modulate the apoptosis-regulating machinery, including the TRAIL signaling pathway.

Conclusions:

  • lncRNAs play a critical role in breast cancer pathogenesis and progression.
  • The interaction between lncRNAs and TRAIL signaling represents a promising avenue for therapeutic intervention.
  • Targeting lncRNA-mediated apoptosis regulation could lead to novel diagnostic and therapeutic strategies for breast cancer.
Keywords:
breast cancerdiagnosislong non-coding RNAtherapeuticstumor necrosis factor-related apoptosis-inducing ligand

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