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Stereoselective Biginelli-like reaction catalyzed by a chiral phosphoric acid bearing two hydroxy groups
Xiaoyun Hu1, Jianxin Guo1, Cui Wang1
1College of Chemistry and Materials South-Central University for Nationalities, Wuhan, China.
Abstract:
To develop new efficient stereoselective catalysts for Biginelli-like reactions, a chiral phosphoric acid bearing two hydroxy groups derived from ʟ-tartaric acid was successfully synthesized via highly regioselective transformations of enantiopure 1,1,4,4-tetraphenylbutanetetraol. The obtained catalyst effectively catalyzed Biginelli-like reactions with moderate to good enantioselectivities. Control experiments indicated that the presence of the two hydroxy groups were indispensable for achieving a high enantioselectivity.
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