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Dehydroxylative Fluorination of Tertiary Alcohols

Wei Zhang1, Yu-Cheng Gu2, Jin-Hong Lin1

  • 1Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

Organic Letters
|August 19, 2020
PubMed
Summary

Synthesizing tertiary C-F bonds is difficult. This study introduces an efficient dehydroxylative fluorination of tertiary alcohols using Selectfluor and a phosphine/diiodoalkane system, achieving moderate to high yields.

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