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Insights from Experiences on Antiplatelet Drugs in Stroke Prevention: A Review

Salvatore Santo Signorelli1,2, Ingrid Platania2, Salvatore Davide Tomasello3

  • 1Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.

International Journal of Environmental Research and Public Health
|August 19, 2020
PubMed

Insights

Preventing stroke and transient ischemic attack (TIA) is crucial. This review examines antiplatelet drug benefits and risks to guide optimal pharmacotherapy for stroke prevention.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Cerebral ischemic events, including stroke and transient ischemic attack (TIA), pose significant health risks.
  • Optimal pharmacotherapy for primary and secondary prevention remains a subject of debate among clinical guidelines and expert opinions.

Purpose of the Study:

  • To review and discuss clinical trial results on antiplatelet agents for stroke prevention.
  • To analyze the benefits and disadvantages of antiplatelet pharmacotherapy in reducing stroke risk.

Main Methods:

  • Systematic review and meta-analysis of clinical trials.
  • Discussion of expert opinions and guidelines.
  • Comparative analysis of antiplatelet drugs (e.g., aspirin) alone or in combination.

Main Results:

  • Antiplatelet agents, including aspirin, are central to stroke prevention strategies.
  • Evidence from trials highlights both the benefits and potential adverse consequences of antiplatelet therapy.
  • Optimal therapeutic approaches vary, necessitating careful consideration of individual patient factors.

Conclusions:

  • A comprehensive understanding of antiplatelet drug efficacy and safety is essential for clinical practice.
  • This review offers a synopsis to guide the most appropriate therapeutic strategies for stroke prevention.
  • Further research may refine optimal pharmacotherapy for reducing the hazard risk of cerebral ischemic events.

Keywords:
aspirincilostazolclopidogrelcombined drug therapydipyridamolepreventionstroke

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