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Perspective on Adversity in Toxicology Evaluations
Jeffery A Engelhardt1, Michael A Dorato2
1Preclinical Development, 448132Ionis Pharmaceuticals, Carlsbad, CA, USA.
Abstract:
Determining adversity of effects in toxicology studies continues to pose a dilemma to practicing toxicologists and pathologists. How this determination is made may follow either a focused or broad approach to assessing the study data. The choice of which approach is best is dependent on a variety of factors. Therefore, we present a philosophical perspective on the determination of adversity across toxicology studies that may be applied in inhalation studies and those conducted by other routes of exposure.
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