Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.4K
Inflammation01:38

Inflammation

60.8K
Overview
60.8K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.2K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.2K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.6K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.6K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of SCF/c-KIT axis in pericyte TNT-guided vessel branching.

Fluids and barriers of the CNS·2026
Same author

Endothelial Cells as Antigen-Presenting Cells. An Historical Note.

Clinical anatomy (New York, N.Y.)·2026
Same author

SEL1L exerts a pro-tumorigenic/pro-angiogenic function in human skin melanoma.

Biochimica et biophysica acta. Molecular cell research·2026
Same author

Transition from two-dimensional to three-dimensional models of endothelial cell cultures.

Anatomical record (Hoboken, N.J. : 2007)·2026
Same author

Gene fusion-driven cutaneous mesenchymal neoplasms: An updated review emphasizing the emerging entities.

Virchows Archiv : an international journal of pathology·2026
Same author

MUC1/CA15-3 identifies a clear cell renal carcinoma characterized by Sunitinib response with a specific metabolic signature.

Clinical and experimental medicine·2026

Related Experiment Video

Updated: Dec 11, 2025

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

10.8K

Mast cells and angiogenesis in multiple sclerosis.

Domenico Ribatti1, Roberto Tamma2, Tiziana Annese2

  • 1Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico, Piazza G. Cesare, 11, 70124, Bari, Italy. domenico.ribatti@uniba.it.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|August 19, 2020
PubMed
Summary

Multiple sclerosis involves central nervous system demyelination. Mast cells contribute to this autoimmune disease by promoting angiogenesis through angiogenic cytokines, influencing MS pathogenesis.

Keywords:
AngiogenesisInflammation mast cellsMultiple sclerosis

More Related Videos

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis
12:29

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis

Published on: May 20, 2012

19.6K
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

24.5K

Related Experiment Videos

Last Updated: Dec 11, 2025

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

10.8K
Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis
12:29

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis

Published on: May 20, 2012

19.6K
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

24.5K

Area of Science:

  • Neuroimmunology
  • Pathophysiology of Multiple Sclerosis
  • Angiogenesis in CNS disorders

Background:

  • Multiple sclerosis (MS) is an autoimmune CNS disease causing demyelination.
  • Chronic inflammation and angiogenesis are increasingly recognized as interconnected in MS.
  • Immune cells secrete angiogenic cytokines, impacting endothelial cells.

Purpose of the Study:

  • To review the role of mast cells (MCs) in multiple sclerosis pathogenesis.
  • To highlight MC involvement in angiogenic processes during MS.

Main Methods:

  • Literature review of studies on mast cells, angiogenesis, and multiple sclerosis.
  • Analysis of immune cell cytokine secretion and endothelial cell interactions.

Main Results:

  • Mast cells are implicated in MS pathogenesis.
  • MCs contribute to the innate immune response in the CNS.
  • These inflammatory cells secrete angiogenic cytokines, promoting endothelial cell activity.

Conclusions:

  • Mast cells play a significant role in multiple sclerosis.
  • Their involvement in angiogenic processes is a key aspect of MS pathogenesis.
  • Understanding MCs' role in angiogenesis may offer therapeutic targets.