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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Related Experiment Video

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Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
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Congenital lung abnormality quantification by computed tomography: The CLAQ method.

Sergei M Hermelijn1, Olivier V Dragt2,3, Jochem J Bosch2,3

  • 1Department of Paediatric Surgery, Erasmus University Medical Centre, Sophia Children's Hospital, Rotterdam, the Netherlands.

Pediatric Pulmonology
|August 19, 2020
PubMed
Summary

A new quantitative computed tomography (CT) scoring method, congenital lung abnormality quantification (CLAQ), objectively assesses congenital lung abnormalities. This method helps predict symptom development and exercise tolerance in affected children.

Keywords:
congenitalcongenital lung malformationscongenital pulmonary airway malformationcystic adenomatoid malformation of lunghigh-resolution computed tomography

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Area of Science:

  • Pediatric Radiology
  • Thoracic Imaging
  • Congenital Abnormalities

Background:

  • Optimal management of congenital lung abnormalities lacks consensus.
  • Predictive factors for postnatal outcomes remain unidentified.

Purpose of the Study:

  • To develop an objective, quantitative computed tomography (CT) scoring method for congenital lung abnormalities.
  • To assess the clinical utility of this scoring method for decision-making and outcome prediction.

Main Methods:

  • Volumetric CT scans of 124 patients (median age 5 months) with congenital lung abnormalities were analyzed.
  • A novel congenital lung abnormality quantification (CLAQ) scoring method was developed, assessing 20 axial slices.
  • CT parameters were correlated with symptom development and 8-year-old spirometry/exercise tolerance (Bruce treadmill test).

Main Results:

  • Congenital pulmonary airway malformation, bronchopulmonary sequestration, and congenital lobar overinflation were common diagnoses.
  • 35% of patients developed symptoms requiring surgery; 22% became symptomatic before CT.
  • Lesional hyperdensity on CT predicted symptom development and reduced exercise tolerance; 18% total disease was an optimal cutoff for symptom development.

Conclusions:

  • The CLAQ method provides an objective and reproducible system for quantifying congenital lung abnormalities on chest CT.
  • Increased risk of symptom development is associated with abnormalities affecting more than one lung lobe.