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Does Subclinical Hypothyroidism Affect Dynamic Thiol / Disulfide Homeostasis and İschemia-modified Albumin Levels in

Serkan Tursun1, Aysegul Alpcan1, Ayca Torel Ergur2

  • 1Department of Pediatrics, Faculty of Medicine, Kirikkale University, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|August 20, 2020
PubMed

Insights

Subclinical hypothyroidism in children may elevate ischemia-modified albumin (IMA), indicating oxidative stress. However, it appears to have no impact on thiol/disulfide balance in pediatric oxidative stress research.

Area of Science:

  • Pediatric Endocrinology
  • Oxidative Stress Research
  • Biochemistry

Background:

  • Subclinical hypothyroidism (SCH) is a condition characterized by elevated thyroid-stimulating hormone (TSH) levels with normal free thyroid hormone levels.
  • Oxidative stress plays a role in various pediatric conditions, but its specific impact in SCH remains unclear.
  • Assessing oxidative stress markers is crucial for understanding the broader health implications of SCH in children.

Purpose of the Study:

  • To investigate the relationship between subclinical hypothyroidism and oxidative stress markers in children.
  • To compare levels of thiol/disulfide balance and ischemia-modified albumin (IMA) between children with and without SCH.
  • To explore potential correlations between TSH levels and oxidative stress indicators.

Main Methods:

  • A cross-sectional study involving 92 children aged 2-18 years, divided into 47 with SCH and 45 healthy controls.
  • Evaluation of native thiol, total thiol, disulfide levels, and their ratios to assess thiol/disulfide balance.
  • Measurement of ischemia-modified albumin (IMA) levels as a marker of oxidative damage.
  • Statistical comparison of oxidative stress markers between groups and assessment of TSH-IMA correlation.

Main Results:

  • No significant differences in age or gender between the SCH and control groups.
  • Thiol/disulfide balance parameters (native thiol, total thiol, disulfides, and ratios) were similar in both groups.
  • Ischemia-modified albumin (IMA) levels were significantly higher in children with subclinical hypothyroidism compared to healthy controls (p<0.001).
  • No significant correlation was found between TSH and IMA levels in the patient group (r=0.069, p=0.645).

Conclusions:

  • Subclinical hypothyroidism in children may be associated with impaired ischemia-modified albumin (IMA) levels, suggesting a link to oxidative stress.
  • The thiol/disulfide balance does not appear to be significantly affected by subclinical hypothyroidism in this pediatric cohort.
  • Further research is warranted to elucidate the precise mechanisms of oxidative stress in pediatric subclinical hypothyroidism.
Abstract

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