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Construction of aptasensors for sensitive detection of 8-OH-dG based on a diffusion mediated electrochemiluminescence
Zhe Feng1, Rui-Juan Zhao1, Ze-Hua Lu2
1Department of Chemistry, Liaocheng University, Liaocheng 252000, China. jialiping@lcu.edu.cn hswang@lcu.edu.cn.
Chemical Communications (Cambridge, England)
|August 20, 2020
Abstract:
A DNA immobilization-free ECL aptasensor was developed for the detection of 8-hydroxy-2'-deoxygunosine based on the diffusion mediated ECL quenching effect. This ECL aptasensor exhibited a high sensitivity and low detection limit by combining homogeneous DNA reaction with dual signal amplifications: target-induced multi-DNA release and Exo I-assisted target recycling.
