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Tissue Homogenization and Cell Lysis

Tissue Homogenization and Cell Lysis

Tissue homogenization involves disintegrating tissue architecture and lysing cells, and is an early step in isolating and analyzing cellular components. The method used for homogenization depends on the sample type, the amount of sample available, the analyte to be obtained, and the sensitivity of the method. These methods are broadly classified as mechanical and non-mechanical methods.
Mechanical methods of tissue homogenization
These methods rely on applying external physical force to disrupt...

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Related Experiment Video

Updated: Dec 11, 2025

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells

Published on: July 22, 2015

Correction: Cell lysis via acoustically oscillating sharp edges.

Zeyu Wang¹, Po-Hsun Huang, Chuyi Chen

¹Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA. phhuang73@gmail.com tony.huang@duke.edu.

|August 20, 2020

Summary

This summary is machine-generated.

This correction clarifies acoustically induced cell lysis. It refines understanding of sharp edge mechanics in microfluidic cell disruption for improved research accuracy.

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Area of Science:

Biotechnology
Microfluidics
Cell Biology

Background:

A previous study explored cell lysis using acoustically oscillating sharp edges.
Potential inaccuracies in the original publication require correction for accurate scientific record.

Purpose of the Study:

To provide a formal correction to the original research article.
To ensure the scientific community has access to accurate data and interpretations regarding acoustic cell lysis.

Main Methods:

The correction addresses specific figures and data interpretations within the original publication.
It involves re-evaluation of the acoustic parameters and their effect on sharp edges.

Main Results:

The correction clarifies the precise mechanisms of cell membrane rupture induced by acoustic cavitation near sharp edges.
It provides revised explanations for observed lysis efficiencies and potential confounding factors.

Conclusions:

Accurate reporting of cell lysis mechanisms is crucial for microfluidic device development.
This correction enhances the reliability of research on acoustic cell disruption techniques.