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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Supramolecular Chemistry

Background:

  • Life relies on enzymatic reactions and noncovalent interactions.
  • Enzymatic noncovalent synthesis (ENS) involves enzymes controlling noncovalent interactions for molecular assembly.
  • ENS explains cellular functions, morphologies, and locations of molecular ensembles.

Purpose of the Study:

  • Summarize recent advancements in ENS over the past decade.
  • Emphasize the functional aspects of ENS.
  • Provide an updated introduction for researchers in molecular science and technology.

Main Methods:

  • Comparison of enzymatic covalent synthesis (ECS) and ENS.
  • Review of natural examples of ENS in cellular processes.
  • Analysis of synthetic ENS in cell-free and cellular contexts.
  • Classification of synthetic ENS by enzyme type.

Main Results:

  • Nature utilizes ENS to form biomacromolecular ensembles with emergent properties.
  • Synthetic ENS has been explored in cell-free systems and within cells.
  • ENS applications include cell morphogenesis, molecular imaging, and cancer therapy.

Conclusions:

  • ENS is a fundamental biological process with significant potential for synthetic applications.
  • Further research in ENS can lead to novel molecular assemblies and technologies.
  • ENS offers promising avenues for addressing societal needs through molecular science.