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Related Experiment Video

Updated: Dec 11, 2025

Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method

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Published on: April 11, 2020

Entropy-Enthalpy Compensation in Peptide Adsorption on Solid Surfaces: Dependence on Surface Hydration.

Xiang Wang¹, Xiao Yang¹, Huijun Chen²

¹College of Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Xinmofanmalu 30, Nanjing 210009, China.

Langmuir : the ACS Journal of Surfaces and Colloids

|August 20, 2020

Summary

This study reveals how water influences protein adsorption on surfaces by analyzing entropy and enthalpy changes. Understanding these thermodynamic factors is key to controlling protein-surface interactions.

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Area of Science:

Physical Chemistry
Surface Science
Biophysics

Background:

Protein adsorption at solid-water interfaces is critical in many applications.
Fundamental thermodynamic data on water's role in protein-surface interactions is scarce.
Interfacial water dynamics significantly influence molecular adsorption behavior.

Purpose of the Study:

To quantify entropy and enthalpy changes during molecular adsorption on solids.
To investigate the role of interfacial water in mediating protein-surface interactions.
To elucidate the entropy-enthalpy compensation mechanisms in water and peptide adsorption on gold and graphene surfaces.

Main Methods:

Advanced free energy calculations were employed.
Entropy and enthalpy changes of molecular adsorption were extracted.
Gold and graphene surfaces were used as model systems with varying water affinities.

Main Results:

Water adsorption is enthalpically dominated, but entropy favorably lowers free energy barriers on graphene.
Peptide adsorption free energy profiles are jointly determined by enthalpy and entropy.
Enthalpy and entropy act as alternative driving forces for peptide adsorption on gold versus graphene.

Conclusions:

The interfacial water phase plays a crucial role in regulating competitive entropy-enthalpy variations.
Distinct solid-liquid interface properties dictate the specific roles of water in adsorption.
Understanding these thermodynamic contributions is vital for designing surfaces with controlled protein interactions.