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Size Does Matter: Litter Size Strongly Determines Adult Metabolism in Rodents
Marcela Parra-Vargas1, Marta Ramon-Krauel1, Carles Lerin1
1Institut de Recerca Sant Joan de Déu, Endocrinology, c/ Santa Rosa 39-57, 4ª planta, Esplugues, 08950 Barcelona, Spain.
Cell Metabolism
|August 20, 2020
Abstract:
In this essay, we highlight how litter size in rodents is a strong determinant of neonatal growth and long-term metabolic health. Based on these effects, we strongly advise that scientific articles that utilize rodent models for obesity and metabolic research should include information on the litter sizes in the study to increase the data transparency of such reports.
