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Updated: Dec 11, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

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Drug-induced sleep endoscopy findings in surgically-naïve obese vs non-obese children

Sarah Lookabaugh1, Margo McKenna1, Sveta Karelsky1

  • 1Department of Otolaryngology Head and Neck Surgery, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, NY, USA.

International Journal of Pediatric Otorhinolaryngology
|August 20, 2020
PubMed

Insights

This study found no significant differences in airway obstruction patterns during drug-induced sleep endoscopy (DISE) between obese and non-obese children with obstructive sleep apnea (OSA). Further research is needed to understand persistent OSA in obese youth.

Area of Science:

  • Pediatric Otolaryngology
  • Sleep Medicine
  • Pediatric Obesity

Background:

  • Obstructive sleep apnea (OSA) is a prevalent condition in children.
  • Obesity is a known risk factor for OSA, but the specific impact on airway obstruction patterns in pediatric patients requires further investigation.
  • Drug-induced sleep endoscopy (DISE) is a valuable tool for assessing airway anatomy during sleep.

Purpose of the Study:

  • To compare drug-induced sleep endoscopy (DISE) findings in obese versus non-obese pediatric patients diagnosed with obstructive sleep apnea (OSA) or sleep-disordered breathing (SDB).
  • To identify potential differences in the patterns and severity of airway obstruction at various anatomic levels between these two groups.

Main Methods:

  • A prospective, observational cohort study included 51 surgically-naïve children aged 2-12 with OSA or SDB.
  • Patients were categorized into obese (BMI ≥ 95th percentile) and non-obese (BMI < 85th percentile) groups.
  • DISE videos were analyzed by blinded pediatric otolaryngologists using a standardized scoring system to assess obstruction at the velum, adenoid, lateral pharyngeal walls, tongue base, and supraglottis.

Main Results:

  • No statistically significant differences in airway obstruction were observed between obese and non-obese children at any of the assessed anatomic airway levels (velum, adenoid, lateral pharyngeal walls, tongue base, supraglottis).
  • The p-values for obstruction at each level ranged from 0.134 to 0.977, indicating no discernible pattern related to obesity status.

Conclusions:

  • The study did not find an association between obesity status and the severity of airway obstruction as determined by DISE in pediatric patients with OSA.
  • Additional research is necessary to explore the underlying reasons for the high incidence of persistent OSA in obese children.
  • Understanding these factors is crucial for developing effective treatment strategies for pediatric OSA in the context of obesity.
Abstract

Keywords:
DISEObesityObstructive sleep apneaPediatricSurgically-naive

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