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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Related Experiment Video

Updated: Dec 11, 2025

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
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Electrically controllable cargo delivery with dextran-rich droplets.

Mengqi Li1, Dongqing Li2

  • 1Department of Marine Engineering, Dalian Maritime University, Dalian 116026, China; Department of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.

Journal of Colloid and Interface Science
|August 20, 2020
PubMed
Summary
This summary is machine-generated.

Electric pulses enable precise control over cargo delivery using droplet carriers. This novel microfluidic technique allows for size-based sorting and targeted delivery of various materials, including biological cells.

Keywords:
Aqueous two-phase systemControlled cargo deliveryMicrodroplet carrierMicrofluidicsParticle sorting

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Area of Science:

  • * Microfluidics and Materials Science
  • * Biotechnology and Drug Delivery

Background:

  • * Controllable cargo delivery is crucial across diverse industries, including medicine, materials science, food, and cosmetics.
  • * Existing methods necessitate the development of novel, precise cargo delivery systems.

Purpose of the Study:

  • * To develop and demonstrate a novel electric pulse-controlled cargo delivery technique using microfluidic droplet carriers.
  • * To investigate the capability for size-based cargo sorting and targeted delivery.
  • * To explore the flexibility and potential applications in biological cargo handling.

Main Methods:

  • * Fabrication of dextran-rich droplet carriers in a continuous polyethylene glycol-rich aqueous two-phase system.
  • * Utilization of microfluidic chips to demonstrate loading and releasing of model cargos (polystyrene particles) via electric pulses.
  • * Controlled manipulation of cargo size sorting and exchange between droplets using electric pulse amplitude and reversal.

Main Results:

  • * Successful loading and releasing of polystyrene particles into droplet carriers controlled by electric pulse amplitude, enabling size-based sorting.
  • * Demonstrated targeted delivery of cargos by size through precise electric pulse control.
  • * Verified flexibility in cargo exchange between droplet carriers using reversed electric pulses and showed potential for biological cargo (yeast cells).

Conclusions:

  • * The developed electric pulse-controlled method offers a novel, flexible, and efficient approach for cargo delivery using droplets.
  • * This technique facilitates precise control over cargo loading, releasing, and sorting based on size.
  • * The method shows promise for applications in biological cargo delivery due to its ease of operation and fast response.