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Updated: Dec 11, 2025

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
Published on: December 17, 2015
Structural Characterization of the Type IX Secretion System in Porphyromonas gingivalis
Dhana G Gorasia1, Eric Hanssen2,3, Paul D Veith4
1Oral Health Cooperative Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, Australia.
Abstract:
The type IX secretion system (T9SS) is the most recently discovered secretion system in the gram-negative bacteria and is specific to the Bacteroidetes phylum. It is comprised of at least 19 proteins, which together allows for the secretion and cell surface attachment of a specific group of proteins (T9SS substrates), that harbor a signal sequence at the C-terminus. Here we describe the structural characterization of the PorK, PorN and PorG components of the Porphyromonas gingivalis T9SS using electron microscopy and cross-linking mass spectrometry.
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