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Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides
Lei Wang1, Hidenori Okamura, Shigeki Sasaki
1Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan. sasaki@phar.kyushu-u.ac.jp taniguch@phar.kyushu-u.ac.jp.
Abstract:
We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2'-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.
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