Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

122
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
122
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

315
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
315
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

532
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
532
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

93
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
93
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

3.1K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
3.1K
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

106
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
106

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Technology for Detecting Keratinocyte Carcinoma From Mohs Micrographic Surgery Fresh Frozen Sections: A Systematic Review of the Literature.

The Australasian journal of dermatology·2025
Same author

Environmental triggers of pemphigus vulgaris and bullous pemphigoid: a case control study.

Frontiers in medicine·2024
Same author

The role of initial lymphatics in the absorption of monoclonal antibodies after subcutaneous injection.

Computers in biology and medicine·2024
Same author

Changes in Human Meibum Lipid Composition Related to the Presence and Severity of Meibomian Gland Dysfunction.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics·2024
Same author

Impact of presbyopia treatment pilocarpine hydrochloride 1.25% on night-driving performance.

Clinical & experimental optometry·2023
Same author

Evaluation of the Impact of Meibomian Gland Dysfunction Using a Novel Patient-Reported Outcome Instrument.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics·2023

Related Experiment Video

Updated: Dec 11, 2025

The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

8.5K

Drug Formulation Impact on Prefilled Syringe Functionality and Autoinjector Performance.

Liang Fang1, Galen Huaiqiu Shi2, Coralie ADÈle Richard3

  • 1West Pharmaceutical Services, Inc.; 530 Herman O. West Drive, Exton, PA 19341; and.

PDA Journal of Pharmaceutical Science and Technology
|August 21, 2020
PubMed
Summary

Early compatibility assessment is crucial for prefilled syringes and autoinjectors. This study reveals formulation excipients drive silicone oil changes, impacting syringe glide force and injection time, necessitating proactive drug-container closure interaction analysis.

Keywords:
AutoinjectorContact angleDrug formulationGlide forceHansen solubility parametersInjection timeInterfacial tensionPrefilled syringeSilicone oil

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.6K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.3K

Related Experiment Videos

Last Updated: Dec 11, 2025

The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

8.5K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.6K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.3K

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Prefilled syringes and autoinjectors are increasingly used, requiring early assessment of drug-container closure interactions.
  • Standard drug stability evaluations must include container closure functionality and device performance over time.
  • Drug formulation variables like excipients and pH can impact syringe functionality.

Purpose of the Study:

  • To elucidate mechanisms causing changes in syringe glide force and injection duration over time.
  • To investigate prolonged and variable autoinjector injection times linked to increased glide force variability.
  • To identify root causes of glide force variability in drug-device combination products.

Main Methods:

  • Orthogonal characterization techniques including contact angle, interfacial tension, and Hansen solubility parameters.
  • Analysis of silicone oil changes in the presence of drug formulation matrices.
  • Evaluation of plunger dimensional variation and silicone oil changes over time.

Main Results:

  • Silicone oil changes are influenced by formulation excipients through "wet, wash, and delube" processes.
  • Accelerated stability of syringe glide force predicts long-term, real-time stability.
  • Buffer matrix-filled syringes can predict the functionality and stability of drug product-filled syringes.

Conclusions:

  • Syringe glide force variability, driven by plunger dimensions and silicone oil changes, impacts autoinjector performance.
  • Understanding silicone oil degradation mechanisms is key to ensuring device reliability.
  • Early compatibility testing using buffer systems can optimize prefilled syringe and autoinjector development.