Blood Eosinophil Count as a Predictor of Lung Function Decline in Healthy Individuals

Little is known about the effect of blood eosinophil count (BEC) on a decline in lung function in healthy individuals.

Using a well-established health screening database, we assessed the associations between BEC and a decline in lung function, measured as the forced expiratory volume in 1 second (FEV₁).

Serial BEC and FEV₁ data were analyzed using linear mixed models adjusted for gender, height, and smoking status. The association between BEC consistency and a decline in FEV₁ was evaluated in subpopulation analyses.

A total of 4634 individuals were enrolled. The mean number of health screenings was 7.49 over an average of 11.74 years of observation. A higher log2-transformed BEC was significantly associated with a greater decline in FEV₁ that was stronger in nonsmokers (P = 8.56 × 10^-8) than in smokers (P = 1.52 × 10^-3). In subpopulation analyses of 2018 individuals with consistent BECs, those with BECs consistently ≥100/μL (P = 4.58 × 10^-6), ≥200/μL (P = 3.53 × 10^-7), and ≥300/μL (P = 1.12 × 10^-3) had a significantly higher dose-dependent FEV₁ decline than those with BECs consistently <100/μL. A BEC threshold of 100/μL in nonsmokers and 200/μL in smokers may predict an accelerated decline in FEV₁.

BEC is associated with a decline in FEV₁, and a consistently high BEC is an independent risk factor for an accelerated decline in FEV₁. These results suggest the use of the BEC to identify healthy individuals at high risk for developing chronic lung disease, which in turn may enable a tailored preventive strategy.