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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Updated: Dec 11, 2025

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Cancer Microbiome; Opportunities and Challenges.

Srivathsa Nallanchakravarthula1, Narayanappa Amruta2, Chitteti Ramamurthy1

  • 1C.G. Bhakta Institute of Biotechnology, UkaTarsadia University, Maliba campus, Bardoli Surat (Dist), Gujarat, India.

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|August 22, 2020
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The cancer microbiome influences tumor metabolism and the tumor microenvironment. Manipulating the microbiome, including through microbiome transplantation, shows promise for cancer therapy and improving clinical outcomes.

Keywords:
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Area of Science:

  • Microbiome research
  • Cancer biology
  • Immunology

Background:

  • The cancer microbiome, comprising microbes associated with cancer, plays a complex role in host physiology.
  • Understanding the cancer microbiome's metabolic plasticity, microenvironment remodeling, and communication is crucial for homeostasis and pathogenesis.
  • The microbiome's impact on cancer initiation, progression, and therapy remains an underexplored area.

Purpose of the Study:

  • To review the role of the microbiome in cancer metabolism and the tumor microenvironment.
  • To explore therapeutic opportunities and challenges in manipulating the cancer microbiome.

Main Methods:

  • Literature search on the microbiome's role in cancer initiation, progression, and therapy.

Main Results:

  • Host-microbiome interactions significantly impact the tumor microenvironment and cancer metabolism.
  • The microbiome can modulate conventional cancer treatments like chemotherapy and immunotherapy.
  • Microbiome transplantation is an emerging and effective therapeutic strategy for cancer.

Conclusions:

  • The tumor microenvironment and cancer metabolism are key areas of host-microbiome interaction.
  • Microbiome modulation offers potential clinical benefits in cancer treatment and modern medicine.