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Related Experiment Video

Updated: Dec 11, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Suppressing Anterior Cingulate Cortex Modulates Default Mode Network and Behavior in Awake Rats.

Wenyu Tu¹, Zilu Ma², Yuncong Ma²

¹Neuroscience Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.

Cerebral Cortex (New York, N.Y. : 1991)

|August 22, 2020

Summary

Researchers explored the default mode network (DMN) in rodents by inactivating a key node, the dorsal anterior cingulate cortex (dACC). Suppressing dACC activity altered DMN function and behavior, revealing its role in rodents.

Keywords:

DREADD awake default mode network rat resting-state fMRI

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Last Updated: Dec 11, 2025

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Published on: May 19, 2015

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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

Area of Science:

Neuroscience
Systems Neuroscience

Background:

The default mode network (DMN) is crucial in humans, but its function and organization in animals are less understood.
Investigating the DMN in rodents offers a model for understanding conserved brain network principles.

Purpose of the Study:

To investigate the causal role of the dorsal anterior cingulate cortex (dACC), a key DMN node, in DMN function and behavior.
To explore the relationship between DMN organization and DMN-relevant behaviors in rodents.

Main Methods:

Combined chemogenetics for targeted dACC inactivation with resting-state functional magnetic resonance imaging (rsfMRI) in awake rodents.
Utilized behavioral tests to assess DMN-related functions post-inactivation.

Main Results:

Suppression of dACC activity significantly altered DMN activity and functional connectivity.
Observed changes in DMN organization were correlated with modifications in DMN-related behaviors.

Conclusions:

The dorsal anterior cingulate cortex (dACC) causally influences default mode network (DMN) function and organization.
Rodent DMN exhibits coordinated activity mediating behavior, similar to humans, validating the chemo-rsfMRI-behavior approach.