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LRP6 lets Merlin go in times of nutrient scarcity
Kenneth Kin Lam Wong1,2, Esther M Verheyen1,2
1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Abstract:
Cells take advantage of cross-talk in signaling pathways to integrate diverse signals and produce coordinated responses. In this issue of EMBO Reports, Jeong et al discover that the Wnt co-receptor, low-density lipoprotein (LDL) receptor-related protein LRP6, negatively regulates Hippo signaling by serving as a binding sink to sequester and inhibit Merlin, an activator of Hippo signaling (Jeong et al, 2020). This regulation is nutrient-responsive, likely using LRP6 O-GlcNAcylation as a molecular switch.
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