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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
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Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
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Mutagenicity and Carcinogenicity01:25

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Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
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RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
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RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem

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Mycotoxin exposure and pregnancy.

İlknur Münevver Gönenç1, Neslihan Yilmaz Sezer1, Serkan Yilmaz1,2

  • 1Faculty of Nursing, Department of Midwifery, University of Ankara, Ankara, Turkey.

Critical Reviews in Toxicology
|August 22, 2020
PubMed
Summary

Mycotoxins, harmful natural toxins, can negatively impact pregnancy outcomes. Avoiding contaminated foods is crucial for maternal and infant health during gestation.

Keywords:
Pregnancymycotoxinspregnancy outcomepregnant women

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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

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RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

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Area of Science:

  • Toxicology
  • Obstetrics
  • Public Health

Background:

  • Pregnancy is a physiological process with inherent risks.
  • Undesirable outcomes like preterm labor and low birth weight occur in a significant number of pregnancies.
  • The multifactorial causes of adverse pregnancy outcomes are not fully understood, with diet playing a role.

Purpose of the Study:

  • To investigate the adverse effects of mycotoxins during pregnancy.
  • To review the evidence linking mycotoxin exposure to negative pregnancy outcomes.
  • To highlight the importance of dietary safety for pregnant women.

Main Methods:

  • Literature review of studies on mycotoxins and pregnancy outcomes.
  • Analysis of mycotoxin exposure routes (direct and indirect).
  • Examination of the toxicological effects of mycotoxins (carcinogenic, teratogenic, mutagenic).

Main Results:

  • Mycotoxins are natural toxins found in agricultural products and animal feed.
  • Evidence suggests mycotoxins can lead to adverse pregnancy outcomes including low birth weight, preterm birth, fetal loss, and defects.
  • Specific negative effects include neonatal jaundice, maternal anemia, and preeclampsia.

Conclusions:

  • Mycotoxin exposure poses risks to pregnant women and fetal development.
  • Further research is needed to fully elucidate the impact of mycotoxins on pregnancy.
  • Dietary vigilance and avoidance of contaminated foods are recommended for pregnant individuals.