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Updated: Dec 11, 2025

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
A Natural Alkaloid, β-Carboline, as a One- and Two-Photon Responsive Fluorescent Photoremovable Protecting Group:
Abstract:
The β-carboline moiety, substituted at the C1 and C3 benzylic positions with a leaving group, has been demonstrated for the first time as a photoremovable protecting group for time-dependent sequential release of two (same or different) carboxylic acids upon one- and two-photon light irradiation. Density functional theory calculations suggest that the electronic environment of the β-carboline moiety at C1 and C3 positions plays a key role in the rate of photorelease.
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