From Seizure Detection to Smart and Fully Embedded Seizure Prediction Engine: A Review

Recent review papers have investigated seizure prediction, creating the possibility of preempting epileptic seizures. Correct seizure prediction can significantly improve the standard of living for the majority of epileptic patients, as the unpredictability of seizures is a major concern for them. Today, the development of algorithms, particularly in the field of machine learning, enables reliable and accurate seizure prediction using desktop computers. However, despite extensive research effort being devoted to developing seizure detection integrated circuits (ICs), dedicated seizure prediction ICs have not been developed yet. We believe that interdisciplinary study of system architecture, analog and digital ICs, and machine learning algorithms can promote the translation of scientific theory to a more realistic intelligent, integrated, and low-power system that can truly improve the standard of living for epileptic patients. This review explores topics ranging from signal acquisition analog circuits to classification algorithms and dedicated digital signal processing circuits for detection and prediction purposes, to provide a comprehensive and useful guideline for the construction, implementation and optimization of wearable and integrated smart seizure prediction systems.