10.5 T MRI static field effects on human cognitive, vestibular, and physiological function.

Area of Science:

• Neuroscience
• Medical Imaging
• Human Physiology

Background:

• Advancements in Magnetic Resonance Imaging (MRI) technology are pushing static field strengths to unprecedented levels.
• Understanding the physiological and cognitive effects of ultra-high field (UHF) MRI is crucial for ensuring subject safety and optimizing imaging protocols.
• Previous research has explored effects at 7T and 9.4T, but data at 10.5T remains limited.

Purpose of the Study:

• To quantitatively assess cognitive, vestibular, and physiological functions during and after exposure to a 10.5 Tesla (T) MRI system.
• To evaluate the effects of 10.5T MRI exposure at multiple short-term and long-term time scales.
• To compare sensory perceptions, including metallic taste, at 10.5T with data from lower field strengths.

Main Methods:

• A pilot study involving 29 subjects exposed to a 10.5T MRI field.
• Comprehensive vestibular, cognitive, and physiological testing conducted before, during, and after MRI exposure.
• Repeated testing and exposure for 26 subjects within a 2-4 week interval to assess long-term effects.
• Analysis of short-term (pre-vs-isocenter, pre-vs-post 1-24h) and long-term (pre-exposures 2-4 weeks apart) changes.

Main Results:

• Out of 79 comparisons, 73 parameters showed no change or minor improvements post-exposure.
• Slight decreases in executive function scores were noted in the short term.
• Increased spontaneous eye movement at isocenter and more videonystagmography abnormalities were observed in the second visit.
• Minor fluctuations in blood pressure were recorded, with no consistent increase.

Conclusions:

• Exposure to 10.5T static magnetic fields did not compromise cognitive performance at isocenter.
• Subjects experienced increased eye movement and minor vital sign changes, but these did not pose safety risks.
• A modified testing protocol was developed to facilitate enrollment and continued monitoring of field effects.