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Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma
Manisha Agarwal1, Chanda Gupta1, K Varsha Mohan2
1Department of Vitreoretina services, Dr Shroff's Charity Eye Hospital, New Delhi, India.
Abstract:
Tubercular granulomas are a common manifestation of intraocular tuberculosis. These are said to be hypoxic granulomas with increased expression of vascular endothelial growth factor (VEGF). Management of these granulomas includes a combination of antitubercular therapy (ATT) and oral corticosteroids. We report a case of tubercular granuloma with exudative retinal detachment which was treated with weekly intravitreal anti-VEGF and antibiotic injections along with ATT and corticosteroids. The VEGF levels measured paralleled with the clinical regression of the granuloma.
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