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Updated: Dec 11, 2025

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Zinc and Traumatic Brain Injury: From Chelation to Supplementation.

Cathy W Levenson¹

¹Department of Biomedical Sciences and Program in Neuroscience, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.

Medical Sciences (Basel, Switzerland)

|August 23, 2020

Summary

Traumatic brain injury (TBI) affects millions globally. Research shows zinc

Keywords:

brain injury chelation excitotoxicity neuroprotection supplementation trauma zinc

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Area of Science:

Neuroscience
Neurobiology
Toxicology

Background:

Traumatic brain injury (TBI) is a significant global health issue, causing millions of disabilities and deaths annually.
Over 30 years of research have elucidated the complex neurochemical, cellular, and molecular mechanisms underlying TBI.
Initial research focused on the neurotoxic effects of excessive zinc accumulation following brain injury.

Purpose of the Study:

To review the evolution of research on zinc's role in traumatic brain injury.
To highlight the expanded understanding of zinc's involvement in TBI pathophysiology and potential therapeutic applications.

Main Methods:

Literature review of research spanning over three decades.
Analysis of studies investigating zinc's neurochemical, cellular, and molecular mechanisms in TBI.
Examination of research on zinc's impact on gene expression, neurogenesis, and cognitive/behavioral deficits post-TBI.

Main Results:

The field has progressed from understanding zinc toxicity to exploring cellular zinc pools after TBI.
Zinc plays a critical role in TBI-regulated gene expression and neurogenesis.
Interventions involving zinc show promise in mitigating cognitive and behavioral impairments following brain injury.

Conclusions:

Research on zinc and TBI has evolved significantly, revealing multifaceted roles beyond initial toxicity.
Understanding zinc's complex involvement offers new avenues for therapeutic strategies to improve outcomes after TBI.
Further investigation into zinc modulation may lead to effective treatments for TBI-related cognitive and behavioral deficits.