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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
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Drug resistant TB spine in a two year old child: A case report
Prathiksha Giridharan1, Elilarasi Selladurai2, Sarath Balaji2
1Department of Clinical Research, ICMR - National Institute for Research in Tuberculosis, Chennai, India.
Insights
Drug-resistant spinal tuberculosis (DR-TB) poses significant risks to children, potentially leading to deformity and neurological issues. This case highlights a challenging pediatric spinal DR-TB presentation unresponsive to standard treatment, emphasizing the need for vigilant monitoring and tailored therapeutic strategies.
Area of Science:
- Pediatric Infectious Diseases
- Orthopedic Surgery
- Mycobacterial Research
Background:
- Spinal tuberculosis (TB) is a severe condition causing deformity and neurological deficits, particularly in pediatric populations.
- Close monitoring of children with spinal TB is crucial for assessing treatment efficacy and clinical progress.
- Indicators for drug-resistant (DR) TB of the spine include prior antituberculous therapy (ATT), non-adherence, known DR-TB contact, or worsening symptoms despite regular ATT.
Abstract:
Spinal tuberculosis (TB) is a disease of high morbidity that is associated with deformity and neurological sequelae, especially in growing children. Children diagnosed with spinal TB need to be monitored closely for clinical improvements. Previous history of antituberculous therapy (ATT), poor adherence to previous ATT, contact with persons having known drug-resistant (DR) TB, or clinical worsening despite regular ATT are strong indicators for the diagnosis of DR TB of the spine. We report a case of spinal DRTB in a two year old child with no previous history of ATT and contact with a person on irregular treatment for drug sensitive TB that did not show regression of the spinal lesions despite standard ATT.
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