Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetically Guided Pharmacotherapy for Structural Neurovascular Lesions.

Neurology. Genetics·2026
Same author

Neurocognitive and affective dysfunction in Chiari malformation type I.

Journal of neurosurgery. Pediatrics·2026
Same author

Neural mechanisms of awareness of action.

PNAS nexus·2026
Same author

Developmental genetic determinants of the human cerebrospinal fluid-ventricular system.

Science translational medicine·2026
Same author

Towards precision medicine for brain arteriovenous malformations.

The Journal of clinical investigation·2026
Same author

An open-access multi-site fMRI dataset for investigating conscious visual perception.

Scientific data·2026

Related Experiment Video

Updated: Dec 11, 2025

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
09:39

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

10.9K

Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior.

Jingwen Xu1,2, Maria Milagros Galardi1, Brian Pok1

  • 1Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 23, 2020
PubMed
Summary

Deep brain stimulation (DBS) of the thalamic central lateral nucleus (CL) reduced slow wave activity and improved behavioral responses in a rat model of the postictal state, offering potential epilepsy treatment.

Keywords:
consciousnessdeep brain stimulationepilepsygeneralized tonic-clonic seizuressleepthalamus

More Related Videos

High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity
06:11

High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity

Published on: September 26, 2025

516
Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.4K

Related Experiment Videos

Last Updated: Dec 11, 2025

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
09:39

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

10.9K
High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity
06:11

High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity

Published on: September 26, 2025

516
Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.4K

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Neuromodulation

Background:

  • The postictal state, following seizures, impairs consciousness and negatively impacts epilepsy patients.
  • Previous research suggests deep brain stimulation (DBS) of the thalamic intralaminar central lateral nucleus (CL) may improve arousal levels in disorders of consciousness.

Purpose of the Study:

  • To investigate the effects of postictal thalamic CL DBS on cortical electrophysiology and behavior in a rat model.
  • To assess the potential of DBS as a therapeutic strategy for improving postictal responsiveness in epilepsy.

Main Methods:

  • Electrical hippocampal stimulation induced secondarily generalized seizures in 21 female rats.
  • Bilateral thalamic CL DBS (100 Hz) was applied during the postictal period.
  • Cortical electrophysiology and behavioral performance on two tasks (licking, shock escape/avoidance) were measured.

Main Results:

  • The postictal state exhibited frontal cortical slow waves and impaired behavioral responses.
  • Thalamic CL DBS prevented postictal slow wave activity and significantly improved performance on the shock escape/avoidance task.
  • Modest behavioral improvement was observed on a spontaneous licking task.

Conclusions:

  • Thalamic CL DBS can decrease postictal cortical slow wave activity and enhance behavioral responsiveness.
  • DBS of subcortical arousal structures presents a potential novel therapeutic strategy for medically and surgically refractory epilepsy.
  • These preclinical findings support the foundation for human neurostimulation trials to improve postictal responsiveness.