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Insightful exploring of microRNAs in psoriasis and its targeted topical delivery

Sai Pradyuth1, Vamshi Krishna Rapalli1, Srividya Gorantla1

  • 1Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India.

Dermatologic Therapy
|August 23, 2020
PubMed

Insights

MicroRNAs (miRNAs) are key players in psoriasis, regulating skin cell growth and inflammation. Topical delivery of miRNAs shows promise for revolutionizing psoriasis treatment and management.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Psoriasis is a prevalent immune-mediated inflammatory skin condition.
  • It involves complex interactions between the immune system and skin keratinocytes.
  • MicroRNAs (miRNAs) are increasingly recognized for their role in keratinocyte hyperproliferation and inflammation in psoriasis.

Purpose of the Study:

  • To highlight the significance of microRNAs (miRNAs) as biomarkers in psoriasis.
  • To explore the potential of miRNA-based therapies for psoriasis treatment.
  • To address the challenges and opportunities in topical miRNA delivery for skin conditions.

Main Methods:

  • Review of recent studies on microRNA (miRNA) deregulation in psoriasis.
  • Analysis of miRNA's role in keratinocyte proliferation and inflammatory cytokine production.
  • Investigation into topical delivery strategies for nucleic acids, including miRNAs.

Main Results:

  • MicroRNA (miRNA) deregulation is a common factor in psoriasis pathogenesis.
  • miRNAs can serve as valuable biomarkers for psoriasis diagnosis, treatment monitoring, and prognosis.
  • Topical delivery of miRNAs presents a viable and potentially revolutionary therapeutic approach.

Conclusions:

  • MicroRNAs (miRNAs) are critical in the immune-mediated mechanisms of psoriasis.
  • Targeting miRNAs offers a promising avenue for novel psoriasis therapies.
  • Advancements in topical delivery systems are crucial for realizing the therapeutic potential of miRNAs in treating skin diseases like psoriasis.
Keywords:
miRNAspsoriasisskin diseasetopical drug delivery

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