Related Experiment Video
Updated: Dec 11, 2025

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
Published on: April 23, 2019
Structure of odorant binding proteins and chemosensory proteins determined by X-ray crystallography
Anaïs Gaubert1, Béatrice Amigues1, Silvia Spinelli1
1Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique (CNRS) & Aix-Marseille Université, Marseille, France.
Abstract:
OBPs and CSPs are small soluble proteins used by organisms as shuttle to transport odorant molecules between air and the membrane-embedded receptors. Deciphering the interactions of these proteins with their ligands at a molecular level may give clue on the function and specificity of the olfactory chain. To reach this goal, protein crystallography is very helpful with more than hundred entries available in the protein data bank (PDB). In this chapter, we present the peculiarities of OBPs and CSPs concerning their crystallization and 3D structure determination by X-ray diffraction.
Related Concept Videos
Olfactory Receptors: Location and Structure
G-Protein Gated Ion Channels
Sensory...
Physiology of Smell and Olfactory Pathway
The olfactory...
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
Olfaction
The olfactory receptors are embedded in the cilia of the...
Protein Organization
The primary structure of a protein is its amino acid sequence....

