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Effect of 0.01% atropine eye drops on choroidal thickness in myopic children
1Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
Insights
Low-dose atropine eye drops significantly thickened the choroid in young myopic children. This choroidal thickness (CT) increase varied by location and treatment duration, offering insights into myopia management.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Myopia Research
Background:
- Myopia is a growing public health concern in children.
- Choroidal thickness (CT) is a key ocular biometric influenced by myopia.
- Low-dose atropine is explored for myopia control.
Purpose of the Study:
- To investigate the impact of 0.01% atropine on choroidal thickness (CT) in young myopic children.
- To assess changes in ocular biometrics alongside CT.
- To analyze the effects in a Shanghai, China population.
Main Methods:
- A cohort of 35 myopic children (59 eyes) received 0.01% atropine treatment.
- Subfoveal CT and ocular biometry were measured using swept-source optical coherence tomography.
- Measurements were taken at baseline and after 2, 4, and 8 weeks of treatment.
Main Results:
- Significant, continuous subfoveal choroidal thickening was observed with atropine treatment.
- The magnitude of CT change varied by anatomical location and treatment duration.
- No significant correlation was found between subfoveal CT changes and axial length.
Conclusions:
- 0.01% atropine eye drops effectively increase choroidal thickness in young myopic children.
- The observed thickening is location-dependent.
- Findings contribute to understanding atropine's ocular effects in pediatric myopia.
Purpose:
To examine the effects of low-dose atropine on the choroidal thickness (CT) of young children in Shanghai, China, as well as the ocular biometrics of myopic patients.
Methods:
A total of 59 eyes of 35 myopic children had subfoveal CT and ocular biometry measurements taken before and after 2weeks, 4weeks, and 8weeks of treatment with 0.01% atropine. All eyes were measured using swept-source optical coherence tomography. CT and changes in it were also recorded.
Results:
The choroid exhibited significant and continuous thickening under the fovea after patients were treated with 0.01% atropine. The magnitude of change in CT varied with the location and with the duration of treatment. The greatest change was observed in the fovea. There was no significant relationship between changes in subfoveal CT and axial length.
Conclusions:
Using 0.01% atropine eye drops significantly increased CT in eyes of young myopic children, by variable magnitude depending upon location.
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