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Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart
M A Nerurkar1, J G Satav, S S Katyare
1Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Diabetologia
|February 1, 1988
Abstract:
Streptozotocin-induced diabetes resulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.