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Updated: Dec 11, 2025

Identification of Circular RNAs using RNA Sequencing
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Circular RNAs: The Brain Transcriptome Comes Full Circle.

Akira Gokool1, Clement T Loy2, Glenda M Halliday3

  • 1School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.

Trends in Neurosciences
|August 25, 2020
PubMed
Summary

Circular RNAs (circRNAs) are abundant in the brain and may play key roles in its function and disorders. This review covers circRNA biogenesis, brain-specific functions, and quantification challenges.

Keywords:
braincircular RNAgene regulationsplicingtranscriptome

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Last Updated: Dec 11, 2025

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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genomics

Background:

  • Circular RNAs (circRNAs) are formed by back-splicing and are found in eukaryotes.
  • circRNAs show cell-type and tissue-specific expression patterns.
  • circRNAs are particularly abundant in the brain, increasing with neuronal differentiation.

Purpose of the Study:

  • To provide an overview of circRNA biogenesis and function.
  • To discuss the contribution of circRNAs to brain transcriptome complexity.
  • To highlight the role of circRNAs in brain disorders and their quantification.

Main Methods:

  • Literature review and synthesis of current research on circRNAs.
  • Analysis of expression patterns in neuronal development and activity.
  • Discussion of challenges in quantifying circRNAs in human brain samples.

Main Results:

  • circRNAs are integral to the brain transcriptome and may have specific functions.
  • circRNAs accumulate during neuronal differentiation and depolarization.
  • Emerging evidence links circRNAs to various brain disorders.

Conclusions:

  • circRNAs represent a significant component of brain RNA with potential functional roles.
  • Understanding circRNA dynamics is crucial for neuroscience and brain disorder research.
  • Accurate quantification methods are needed for studying circRNAs in postmortem human brain.