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Abnormal Effective Connectivity Underlying Auditory Mismatch Negativity Impairments in Schizophrenia

Daisuke Koshiyama1, Makoto Miyakoshi2, Yash B Joshi1

  • 1Department of Psychiatry, University of California San Diego, San Diego.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|August 25, 2020
PubMed
Summary

Auditory mismatch negativity (MMN) reduction in schizophrenia is linked to altered temporofrontal brain connectivity. Impaired MMN in patients involves frontal midline sources and abnormal network dynamics, correlating with symptom severity.

Keywords:
Effective connectivityMismatch negativity (MMN)Negative symptomsSchizophreniaSource-level analysisTranslatable biomarker

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