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Taxifolin tubes: crystal engineering and characteristics.

Roman P Terekhov1, Irina A Selivanova1, Nonna A Tyukavkina1

  • 1Department of Chemistry, Sechenov First Moscow State Medical University, Trubetskaya st. 8-2, Moscow, 119991, Russian Federation.

Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
|August 25, 2020
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Summary

Researchers developed novel taxifolin microtubes from larch wood, a potent antioxidant. This new crystalline form exhibits distinct properties from raw taxifolin, achieved through crystal engineering with urea.

Keywords:
X-ray diffractioncomputational materials sciencecrystal engineeringspectroscopytaxifolin

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Area of Science:

  • Natural Product Chemistry
  • Materials Science
  • Crystallography

Background:

  • Taxifolin (dihydroquercetin) is a major antioxidant flavonoid found in larch wood.
  • It is industrially produced as a crystalline active pharmaceutical ingredient.
  • Existing research includes nano- and microstructured taxifolin particles.

Purpose of the Study:

  • To report the generation of a new taxifolin microtube form.
  • To optimize conditions for microtube yield.
  • To characterize the physicochemical properties of the new form.

Main Methods:

  • Crystal engineering of raw taxifolin with urea at ambient conditions.
  • Optimization of temperature, pH, molar ratio, and time.
  • Characterization using X-ray diffraction, microscopy, spectroscopy (NMR, UV, FTIR), and mass spectrometry.
  • Computer simulations for self-assembly mechanism analysis.

Main Results:

  • Successful generation of taxifolin microtubes via self-assembly with urea.
  • Optimized parameters for enhanced microtube yield.
  • Established water solubility and melting point of the new form.
  • Demonstrated identical crystal unit structure but different morphological and physicochemical properties compared to raw taxifolin.

Conclusions:

  • A novel microtube form of taxifolin was successfully synthesized and characterized.
  • The process involves crystal engineering with urea, yielding a distinct material.
  • The findings offer new insights into taxifolin's structural versatility and potential applications.