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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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ONS Guidelines™ for Cancer Treatment-Related Skin Toxicity.

Loretta A Williams1, Pamela K Ginex2, George L Ebanks3

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Summary
This summary is machine-generated.

This guideline provides recommendations for managing cancer treatment-related skin toxicities, such as EGFR inhibitor rash and chemotherapy-induced alopecia, to improve patient well-being and minimize treatment disruptions.

Keywords:
GRADEalopeciaguidelinesside effect managementskin toxicities

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Area of Science:

  • Oncology
  • Dermatology
  • Evidence-based practice

Background:

  • Cancer treatments can cause significant skin toxicities, impacting patient quality of life.
  • Effective management of these toxicities is crucial for patient well-being and treatment adherence.

Purpose of the Study:

  • To develop a guideline for managing cancer treatment-related skin toxicities.
  • To support shared decision-making between patients and clinicians.

Main Methods:

  • Guideline development followed GRADE criteria for evidence certainty and National Academies criteria for trustworthiness.
  • Risk of bias was assessed using the Cochrane risk-of-bias tool.
  • Evidence was synthesized through quantitative or narrative methods.

Main Results:

  • Seven conditional recommendations were issued for EGFR inhibitor rash, hand-foot skin reaction/syndrome, and chemotherapy-induced alopecia.
  • Prevention and treatment strategies were suggested for most toxicities.
  • Only a prevention recommendation was made for hand-foot syndrome.

Conclusions:

  • Implementing these guideline recommendations can improve patient outcomes.
  • Addressing skin toxicities is vital for enhancing the quality of life during cancer treatment.