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Cherry angioma: A case-control study
Ramah I Nazer1, Rahaf H Bashihab2, Wedad H Al-Madani3
1Department of Medicine, Division of Dermatology, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Insights
Tamsulosin may increase cherry angioma risk, while clopidogrel appears to protect against their development. Further research is needed to confirm these associations for common vascular skin lesions.
Area of Science:
- Dermatology
- Vascular Lesions
- Epidemiology
Background:
- Cherry angiomas (CAs) are common, asymptomatic vascular skin lesions.
- Limited research exists on CA risk factors.
Purpose of the Study:
- To identify risk factors associated with the development of cherry angiomas.
Main Methods:
- A case-control study was conducted with 300 participants (100 cases, 200 controls).
- Data on demographics, medical history, and medications were collected from electronic records.
Main Results:
- Tamsulosin use was independently associated with an increased risk of CAs (OR = 3.475, P = 0.009).
- Clopidogrel use was independently associated with a reduced risk of CAs (OR = 0.281, P = 0.028).
- Benign prostatic hyperplasia and malignancy showed associations but did not reach statistical significance in multivariate analysis.
Conclusions:
- Tamsulosin is a potential risk factor for cherry angioma development.
- Clopidogrel may play a protective role in preventing cherry angiomas.
Background:
Cherry angiomas (CAs) are very common asymptomatic vascular skin lesions. There are only a few studies on CAs in the literature and those assessing risk factors of CAs are scarce. The aim of our study was to determine risk factors for the development of CAs.
Materials And Methods:
A case-control study was conducted at a tertiary care center in Riyadh, Saudi Arabia. Patients underwent a full-body examination for CAs. Demographics and other data including medical history and medications were extracted from electronic medical records.
Results:
A total of three hundred patients were enrolled: one hundred cases with at least five CAs and two hundred controls without CAs. Bivariate analysis identified benign prostatic hyperplasia (odds ratio [OR]: = 2.591), malignancy (OR = 2.567), tamsulosin (OR = 3.171), and clopidogrel (OR = 0.321) as statistically significant associations. After multivariate logistic regression analysis, only tamsulosin (OR = 3.475, P = 0.009) and clopidogrel (OR = 0.281, P = 0.028) were found to be independent risk factors for CAs. Malignancies tended to be more associated with CAs, but this did not reach statistical significance (P = 0.07).
Conclusion:
Tamsulosin is a possible risk factor for the development of CAs. Clopidogrel seems to have a protective role preventing the development of CAs.
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