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Interpreting MAIA Microperimetry Using Age- and Retinal Loci-Specific Reference Thresholds.

Jason Charng1, Paul G Sanfilippo1,2, Mary S Attia1

  • 1Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, Western Australia.

Translational Vision Science & Technology
|August 25, 2020
PubMed
Summary
This summary is machine-generated.

The standard 25 decibel (dB) cutoff for Macular Integrity Assessment (MAIA) microperimetry may misinterpret results. An age- and location-specific criterion is recommended for accurate assessment of retinal sensitivity.

Keywords:
MAIAcone-rod dystrophyhydroxychloroquine toxicitymaculamicroperimetryretinal sensitivity

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Area of Science:

  • Ophthalmology
  • Visual Neuroscience

Background:

  • Macular Integrity Assessment (MAIA) microperimetry is crucial for evaluating paracentral scotoma in clinical trials and practice.
  • Current MAIA interpretation relies on a uniform 25 decibel (dB) cutoff, disregarding age and retinal location.

Purpose of the Study:

  • To establish an age- and loci-specific reference for MAIA sensitivity in healthy eyes.
  • To compare this new reference criterion against the conventional <25 dB cutoff.

Main Methods:

  • Retrospective analysis of MAIA results from healthy eyes.
  • Quantile regression was used to derive age-specific sensitivity cutoffs at the 2.5th percentile for each locus.
  • Two clinical cases were analyzed using both the new and conventional methods.

Main Results:

  • A significant percentage of healthy eyes showed sensitivity <25 dB, particularly in older subjects and specific retinal regions.
  • Age-related decline in retinal sensitivity was observed, with a median gradient of 0.6 dB/decade.
  • The prevalence of <25 dB sensitivity was 5% for the small grid and 10% for the large grid.

Conclusions:

  • The uniform <25 dB cutoff for MAIA interpretation is potentially inaccurate.
  • An age- and loci-specific criterion is advocated for more precise MAIA analysis.
  • MAIA interpretation is significantly influenced by the chosen criterion for defining abnormal measurements.