Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

206
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
206
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

177
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
177
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.0K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.0K
Friedman Two-way Analysis of Variance by Ranks01:21

Friedman Two-way Analysis of Variance by Ranks

414
Friedman's Two-Way Analysis of Variance by Ranks is a nonparametric test designed to identify differences across multiple test attempts when traditional assumptions of normality and equal variances do not apply. Unlike conventional ANOVA, which requires normally distributed data with equal variances, Friedman's test is ideal for ordinal or non-normally distributed data, making it particularly useful for analyzing dependent samples, such as matched subjects over time or repeated measures...
414
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

207
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
207
Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

307
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
307

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.

The journal of pain·2026
Same author

Variation in early-life maltreatment effects on adolescent psychopathology due to contamination.

Journal of traumatic stress·2026
Same author

Defining the <i>r</i> factor for post-trauma resilience and its neural predictors.

Nature. Mental health·2025
Same author

Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.

Nature. Mental health·2025
Same author

Childhood Adversity Is Associated With Longitudinal White Matter Changes After Adulthood Trauma.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2025
Same author

Smartphone language features may help identify adverse post-traumatic neuropsychiatric sequelae and their trajectories.

NPP - digital psychiatry and neuroscience·2025

Related Experiment Video

Updated: Dec 11, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.6K

An Instrumental Variable Estimator for Mixed Indicators: Analytic Derivatives and Alternative Parameterizations.

Zachary F Fisher1, Kenneth A Bollen2

  • 1University of North Carolina at Chapel Hill, Chapel Hill, USA. fish.zachary@gmail.com.

Psychometrika
|August 25, 2020
PubMed
Summary

This study introduces a novel approach to the model-implied instrumental variable (MIIV) estimation framework, extending its application to mixed-type variables and enhancing its analytical capabilities for structural equation modeling (SEM). The new method offers improved parameter estimation for complex data structures.

Keywords:
continuous variablesdichotomous variablesestimationfactor analysisinstrumental variableslatent variablesordinal variablesstructural equation modelingtwo-stage least squares (2SLS)

More Related Videos

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
08:27

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits

Published on: September 27, 2019

7.2K
The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

6.2K

Related Experiment Videos

Last Updated: Dec 11, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.6K
Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
08:27

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits

Published on: September 27, 2019

7.2K
The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

6.2K

Area of Science:

  • Statistics
  • Econometrics
  • Psychometrics

Background:

  • The model-implied instrumental variable (MIIV) estimation framework has seen significant methodological development over three decades.
  • Prior work established MIIV for continuous and ordered categorical endogenous variables, and introduced generalized method of moments estimators.

Purpose of the Study:

  • To advance the MIIV estimation framework by introducing novel analytical and methodological contributions.
  • To extend the applicability of MIIV to a broader range of data types and model specifications within SEM.

Main Methods:

  • Derivation of analytic derivatives for the PIV estimator using matrix calculus.
  • Extension of the PIV estimator to handle mixtures of binary, ordinal, and continuous variables.
  • Generalization of the PIV model to incorporate intercepts and means, and inputting known threshold values for ordinal variables.

Main Results:

  • The paper presents a generalized PIV model capable of estimating means, variances, and covariances for underlying variables in SEM.
  • An empirical example demonstrates the application to a mixture of continuous and ordinal variables with fixed thresholds.
  • A simulation study compares the novel estimator's performance against the WLSMV estimator.

Conclusions:

  • The developed PIV estimator offers a versatile and robust method for SEM analyses involving mixed-type variables.
  • This methodological advancement expands the utility of instrumental variable approaches in statistical modeling.
  • The findings suggest the novel estimator is a viable alternative to existing methods like WLSMV for complex data structures.