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Ewa M Musiol-Kroll1, Wolfgang Wohlleben1

  • 1Interfakultäres Institut für Mikrobiologie und Infektionsmedizin (IMIT), Mikrobiologie/Biotechnologie Eberhard Karls Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Deutschland.

Biospektrum : Zeitschrift Der Gesellschaft Fur Biologishe Chemie (GBCH) Und Der Vereinigung Fur Allgemeine Und Angewandte Mikrobiologie (VAAM)
|August 25, 2020
PubMed
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Polyketides (PKs) are compounds with diverse medicinal properties. Engineering the enzymes (PKSs) that produce them offers a route to novel drug derivatives with enhanced therapeutic potential.

Area of Science:

  • Biochemistry and Molecular Biology
  • Natural Product Chemistry

Context:

  • Polyketides (PKs) are a diverse class of secondary metabolites.
  • These compounds exhibit a wide range of valuable biological activities, including antibiotic, antifungal, antiviral, anticancer, and immunosuppressive properties.

Purpose:

  • To explore the biosynthesis of polyketides.
  • To investigate the potential for engineering polyketide synthases (PKSs) for novel drug discovery.

Summary:

  • Polyketides are synthesized by large, multifunctional enzymes known as polyketide synthases (PKSs).
  • The modular nature of PKS enzymes presents opportunities for genetic manipulation and protein engineering.
  • Engineering PKSs can lead to the generation of novel polyketide derivatives.

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Impact:

  • Development of new therapeutic agents with improved pharmacokinetic profiles.
  • Expansion of the spectrum of bioactivity for existing or novel polyketide-based drugs.
  • Advancement in the field of synthetic biology for natural product drug discovery.