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Acute Multivessel Coronary Occlusion Revealing COVID-19 in a Young Adult

Sandra Zendjebil1, Michel Zeitouni1, Marc Batonga1

  • 1ACTION (Allies in Cardiovascular Trials Initiatives and Organized Networks) Study Group, Sorbonne Université, INSERM UMRS 1166, Institut de Cardiologie, Hôpital Pitié-Salpêtrière, Paris, France.

JACC. Case Reports
|August 25, 2020
PubMed

Insights

A young man experienced ST-elevation myocardial infarction due to acute coronary thrombosis. This event was linked to a severe acute respiratory syndrome-coronavirus-2 infection, highlighting a potential cardiovascular risk.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Vascular Biology

Background:

  • ST-elevation myocardial infarction (STEMI) typically affects older individuals with established cardiovascular risk factors.
  • Multivessel coronary artery occlusion is a severe presentation of acute coronary syndrome.
  • Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection has been associated with various cardiovascular complications.

Observation:

  • A 42-year-old male patient presented with STEMI.
  • The patient exhibited acute thrombosis in the left anterior descending and right coronary arteries.
  • The patient had no significant pre-existing cardiovascular risk factors.
  • The patient tested positive for SARS-CoV-2 infection.

Findings:

  • Acute multivessel coronary occlusion in a young, low-risk individual.
  • Positive SARS-CoV-2 test correlating with acute myocardial infarction.
  • Demonstration of severe acute respiratory syndrome-coronavirus-2 as a potential trigger for acute coronary thrombosis.

Implications:

  • SARS-CoV-2 infection may precipitate acute coronary thrombosis and myocardial infarction in young, otherwise healthy individuals.
  • This case underscores the importance of considering COVID-19 in the differential diagnosis of acute coronary syndromes, irrespective of age or traditional risk factors.
  • Further research is warranted to elucidate the mechanisms linking SARS-CoV-2 infection to coronary artery thrombosis.

Keywords:
COVID-19, coronavirus-2019SARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2STEMI, ST-segment elevation myocardial infarctionULN, upper limit of normal valueacute coronary syndromearterial thrombosiscoronavirus disease-2019myocardial infarction

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