Predisposition or Protection?: COVID-19 in a Patient on LVAD Support With HIV/AIDS
Kiran Mahmood1, Eman R Rashed1, Estefania Oliveros1
1Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
JACC. Case Reports
|August 25, 2020
Summary
Researchers explored coronavirus disease-2019 (COVID-19) treatment in a unique patient with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). This case study details the patient's recovery from COVID-19, offering insights into potential therapeutic effects.
Area of Science:
- Infectious Diseases
- Virology
- Immunology
Background:
- The search for effective coronavirus disease-2019 (COVID-19) therapies is ongoing.
- Patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) present a unique cohort for studying COVID-19 clinical courses.
- Antiretroviral therapy (ART) in HIV/AIDS patients may influence COVID-19 outcomes.
Observation:
- A case report of a patient with HIV/AIDS on left ventricular assist device (LVAD) support is presented.
- The patient was hospitalized with COVID-19.
- The patient successfully recovered from COVID-19.
Findings:
- This case highlights the recovery of an immunocompromised patient with significant comorbidities from COVID-19.
- The clinical course suggests that existing antiretroviral therapies might play a role in managing COVID-19 in HIV/AIDS patients.
Implications:
- Further research into the interaction between antiretroviral therapy and COVID-19 is warranted.
- This case contributes to understanding COVID-19 in vulnerable populations.
- Insights may guide the development of targeted COVID-19 treatment strategies for immunocompromised individuals.
Keywords:
AIDS, acquired immunodeficiency syndromeART, antiretroviral therapyCOVID-19, coronavirus disease-2019HIV, human immunodeficiency virusHIV/AIDSIL, interleukinLVADLVAD, left ventricular assist deviceSARS, severe acute respiratory syndromeSARS-CoV-2, severe acute respiratory syndrome-coronavirus-2antiretroviral therapycoronavirus diseasemechanical circulatory support
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