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Updated: Dec 11, 2025

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Excessive daytime sleepiness after traumatic brain injury
Thomas Crichton1, Rajiv Singh1,2, Kessewa Abosi-Appeadu3
1Department of Neuroscience, University of Sheffield , Sheffield, UK.
Study Objectives:
To identify the prevalence of excessive daytime sleepiness (EDS) in a prospectively recruited patient population with traumatic brain injury (TBI) of mixed severity. Furthermore, the study aimed to assess the relationship between patient factors and EDS.
Method:
One-hundred and eighteen patients with TBI were assessed in a neurorehabilitation clinic after discharge from the emergency department. Enrolled participants were evaluated using several TBI-related outcome measures, 6-8 weeks after injury.
Results:
EDS (defined using the Epworth Sleepiness Scale ≥10) occurred in 48 of 118 (41.7%) patients in this study. Anxiety; depression; change in ability to work; employment status; global outcome (GOSE); social and functional outcome (RHFUQ); and symptom severity (RPCS) were associated with EDS in a univariate analysis. Anxiety was the only factor associated with EDS in the multivariate analysis (OR: 0.28 [95% CI: 0.09-0.90], P = .032).
Conclusion:
EDS is common after TBI in a community setting and is associated with several factors, which likely interact to contribute toward worse outcome. Anxiety is a factor that, if routinely assessed and considered during patient care choices, may assist in favorable sleep-related outcome during and after post-TBI recovery.
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