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Nucleoside Analogs with Fleximer Nucleobase.

Mikhail V Chudinov1

  • 1MIREA - Russian Technological University, Lomonosov Institute of Fine Chemical Tehnology, 78 Vernadsky Ave, Moscow, 119454 Russia.

Chemistry of Heterocyclic Compounds
|August 25, 2020
PubMed
Summary

Fleximer nucleoside analogs, with rotatable bases, show promise as molecular probes and exhibit significant antiviral and antitumor activity. This review details their synthesis, structure, and biological applications.

Keywords:
antitumor activityantiviral activityfleximernucleoside analogspyrimidineribosidetriazole

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Area of Science:

  • Medicinal Chemistry
  • Molecular Biology
  • Organic Chemistry

Background:

  • Fleximer nucleoside analogs feature multiple planar bases linked by a rotatable bond.
  • Initially developed as molecular probes for nucleic acid processes.
  • Emerging interest due to potent antiviral and antitumor properties.

Purpose of the Study:

  • To review the synthesis methods of fleximer nucleoside analogs.
  • To analyze the structural characteristics of these compounds.
  • To summarize their diverse biological activities, particularly antiviral and antitumor effects.

Main Methods:

  • Literature review of synthesis strategies for fleximer nucleoside analogs.
  • Analysis of structural data and conformational flexibility.
  • Compilation and assessment of reported biological activity data.

Main Results:

  • Overview of various synthetic routes enabling fleximer nucleoside analog production.
  • Correlation between structural features and biological efficacy.
  • Demonstration of significant antiviral and antitumor potential in preclinical studies.

Conclusions:

  • Fleximer nucleoside analogs represent a promising class of compounds with dual applications.
  • Their unique structure facilitates enzyme-substrate interaction studies and therapeutic development.
  • Further research is warranted to explore their full therapeutic potential.