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Related Experiment Video

Updated: Dec 11, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Animal Models to Study Emerging Technologies Against SARS-CoV-2.

Jhinuk Basu Mullick¹, Chelsey S Simmons^1,2, Janak Gaire¹

¹Department of Mechanical & Aerospace Engineering, Herbert Wertheim College of Engineering, University of Florida, PO Box 116250, Gainesville, FL 32611 USA.

Cellular and Molecular Bioengineering

|August 25, 2020

Summary

Traditional animal models like mice are limited for studying SARS-CoV-2. Non-human primates, hamsters, ferrets, cats, and engineered chimeras better mimic human infection, offering potential for COVID-19 research and therapeutic development.

Keywords:

ACE2 receptor COVID-19 Diagnostics Domestic pets Farm animals Non-human primates Pathogenesis Transgenic models Vaccine studies

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Area of Science:

Virology
Infectious Diseases
Preclinical Research

Background:

Novel coronavirus SARS-CoV-2 necessitates advanced research tools.
Understanding pathogenesis, transmission, and developing countermeasures requires suitable animal models.
Common laboratory rodents exhibit limitations in mimicking human SARS-CoV-2 infection.

Purpose of the Study:

To review animal models for SARS-CoV-2 research.
To aid bioengineers in selecting appropriate preclinical models.
To evaluate viral infection, transmission, and clinical presentation in different animal models.

Main Methods:

Review of existing and developing animal models for SARS-CoV-2.
Analysis of viral infection, transmission, and clinical presentation similarities to humans.
Evaluation of model suitability for therapeutic and vaccine development.

Main Results:

Traditional mice and rat models have limited applications for SARS-CoV-2 and COVID-19.
Non-human primates, Syrian hamsters, ferrets, cats, and engineered chimeras show greater promise.
These models more closely mimic human infection and disease progression.

Conclusions:

Certain animal models are crucial for advancing SARS-CoV-2 research.
Selecting appropriate models is vital for effective preclinical testing of emerging technologies.
Advanced models like non-human primates and engineered chimeras offer significant potential for COVID-19 studies.