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Multi-triazole-resistant Aspergillus fumigatus and SARS-CoV-2 co-infection: A lethal combination

Aia Mohamed1, Tidi Hassan2, Marta Trzos-Grzybowska1

  • 1Department of Microbiology, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland.

Medical Mycology Case Reports
|August 25, 2020
PubMed

Insights

Severe COVID-19 pneumonia can be complicated by invasive aspergillosis. Early detection of triazole-resistant Aspergillus fumigatus is crucial for effective antifungal treatment in these critical patients.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • COVID-19 (coronavirus disease 2019) can lead to severe pneumonia.
  • Invasive fungal infections, such as aspergillosis, are serious complications in immunocompromised patients.
  • Co-infections with Aspergillus species can worsen outcomes in severe respiratory illnesses.

Observation:

  • A case of severe COVID-19 pneumonia with a fatal co-infection is presented.
  • The co-infection involved a multi-triazole resistant strain of Aspergillus fumigatus.
  • Isolation of Aspergillus species from respiratory samples in COVID-19 patients is significant.

Findings:

  • Multi-triazole resistance in Aspergillus fumigatus poses a significant challenge.
  • Standard antifungal therapies may be ineffective against resistant strains.
  • The study underscores the critical nature of Aspergillus co-infection in severe COVID-19.

Implications:

  • Early diagnosis and recognition of Aspergillus sp. are vital for patient management.
  • Prompt detection of triazole resistance is essential for selecting appropriate antifungal agents.
  • Improved outcomes in coronavirus-associated invasive aspergillosis depend on timely and accurate diagnosis and treatment.
Keywords:
COVID-19 pneumoniaInvasive pulmonary aspergillosisMulti-triazole resistance

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