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Updated: Dec 11, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Psychometric properties of the Pandemic-Related Pregnancy Stress Scale (PREPS)
Heidi Preis1, Brittain Mahaffey2, Marci Lobel1
1Department of Psychology, Stony Brook University, Stony Brook, NY, USA.
Purpose:
Pregnant women are facing numerous COVID-19 related burdens including social isolation, financial insecurity, uncertainty about the impact of the virus on fetal development, and prenatal care restrictions. We tested the psychometric properties of a new instrument designed to assess the extent and types of pandemic-related stress experienced by pregnant women.
Materials And Methods:
4,451 pregnant women from across the U.S. were recruited via social media and completed an online questionnaire in April-May 2020. The questionnaire included measures of psychological, sociodemographic, and obstetric factors and the new Pandemic-Related Pregnancy Stress Scale (PREPS).
Results:
Confirmatory factor analyses of the PREPS showed excellent model fit. Three factors - Perinatal Infection Stress (5 items), Preparedness Stress (7 items), and Positive Appraisal (3 items) - converged and diverged with expected psychological factors, and scales created from these factors demonstrated acceptable to good reliability (α's 0.68-0.86). In addition, mean PREPS scores were associated with perceived risk of infection, and with financial and vocational COVID-19 related burdens.
Conclusion:
The PREPS is a robust instrument to assess multidimensional COVID-19 pandemic prenatal stress. It is a valuable tool for future research to examine vulnerability to pandemic stress and how this stress may affect women and their offspring.
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