Development and Validation of a Modified Three-Dimensional U-Net Deep-Learning Model for Automated Detection of Lung Nodules on Chest CT Images From the Lung Image Database Consortium and Japanese Datasets
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Published on: September 11, 2021
Kazuhiro Suzuki1, Yujiro Otsuka2, Yukihiro Nomura3
1Department of Radiology, Juntendo University Faculty of Medicine and Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.
Rationale And Objectives:
A more accurate lung nodule detection algorithm is needed. We developed a modified three-dimensional (3D) U-net deep-learning model for the automated detection of lung nodules on chest CT images. The purpose of this study was to evaluate the accuracy of the developed modified 3D U-net deep-learning model.
Materials And Methods:
In this Health Insurance Portability and Accountability Act-compliant, Institutional Review Board-approved retrospective study, the 3D U-net based deep-learning model was trained using the Lung Image Database Consortium and Image Database Resource Initiative dataset. For internal model validation, we used 89 chest CT scans that were not used for model training. For external model validation, we used 450 chest CT scans taken at an urban university hospital in Japan. Each case included at least one nodule of >5 mm identified by an experienced radiologist. We evaluated model accuracy using the competition performance metric (CPM) (average sensitivity at 1/8, 1/4, 1/2, 1, 2, 4, and 8 false-positives per scan). The 95% confidence interval (CI) was computed by bootstrapping 1000 times.
Results:
In the internal validation, the CPM was 94.7% (95% CI: 89.1%-98.6%). In the external validation, the CPM was 83.3% (95% CI: 79.4%-86.1%).
Conclusion:
The modified 3D U-net deep-learning model showed high performance in both internal and external validation.